Breast cancer is a malignant tumor that develops from breast tissue. The most obvious symptom of breast cancer is typically a lump in the breast. The primary types of breast cancer are ductal carcinoma and lobular carcinoma.
Breast cancer incidence rates have been steadily increasing since the 1970s. Worldwide, breast cancer is the leading type of cancer in women, accounting for 25% of all cases. In 2012 it resulted in 1.68 million cases and 522,000 deaths. It is more common in developed countries and is >100 times more common in women than in men.
Breast cancer is a heterogeneous disease with a high degree of diversity in histopathology, and correspondingly it can be divided into categories according to the grade/stage and the expression of proteins and genes of the tumor. Breast cancer can be classified into five major intrinsic subtypes: luminal A, luminal B, HER2/Neu-enriched, basal-like, and normal-like breast cancer. In clinic, breast cancer is also defined as triple-negative and non triple-negative breast cancer according to ER,PR,and HER2 expression. Different subtypes have different gene expression profiling, therapeutic scheme and prognosis.
A lot of challenges are still on the road to the precise diagnosis and treatment of breast cancer. Further researches on molecular mechanisms and biomarkers of breast cancer are still urgently needed.
Wu, J.et al. BCIP: a gene-centered platform for identifying potential regulatory genes in breast cancer. Scientific Reports. 7: 45235 (2017).
|Samples with CNV||3035|
|Samples with survival||8086|
|Samples with treatment||4014|
|Samples in PAM50 subtype (Basal-like/
Nov 6, 2016: Version 1.0 released.
Oct 9, 2016: Created and beautified the Home page of our website, and added supplementary information of Help page contains tutorial document on how to use our platform analytical tools.
Sep 16, 2016: Three other types data (miRNAs, Pathways, Gene functional network) have been added to the platform. Subsequently updated Analysis Type and results display of Database page.
Jul 13, 2016: 29 breast cancer gene expression data sets and 2 copy number variation data sets have been added, and we have provided Database page for integrated investigation.